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Jeffries, who addressed supporters after House control was called for Democrats, argued voters have sent Congress a message to end extremism and "corruption."
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Talarico defeated Republican state Attorney General Ken Paxton, a close ally of President Trump.
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Missouri voters have denied a Republican-backed congressional map that wound its way through the courts before ultimately ending up on the state's ballot.
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Democratic former U.S. Sen. Sherrod Brown has won back a seat on Capitol Hill, defeating incumbent Republican Sen. Jon Husted after a close and expensive battle, according to a race call by the Associated Press.
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NPR's Juana Summers talks with former Trump aide Sonny Joy Nelson about where some GOP candidates fell short tonight.
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Democrat James Talarico has won the Senate seat in Texas, according to a race call by the Associated Press.
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Democrat Amy Acton beat biotech entrepreneur Vivek Ramaswamy, a Republican backed by President Trump, in a race marked in the final weeks by a Ramaswamy attack ad that drew national criticism.
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The candidates tapped into voter frustration with the political status quo and will now look to translate their success into policy wins that push Democrats further to the left.
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NPR's Scott Detrow talks with Rahm Emanuel, who served as Chicago mayor and chief of staff to President Obama.