Early in life, the protein Reelin helps assemble the brain. Later on, it appears to protect the organ from Alzheimer’s and other threats to memory and thinking.
A new generation of blood tests can help doctors diagnose Alzheimer's without a brain scan or spinal tap. But only a few perform as well as traditional tests.
In a large study, the experimental drug donanemab slowed the progression of Alzheimer's by about 35%. That's slightly better than the drug Leqembi, which was fully approved by the FDA on July 6.
In a large study, the experimental Alzheimer's drug lecanemab reduced the rate of cognitive decline by 27 percent in people in the early stages of the disease.
The FDA has until Monday to decide whether to approve the first new Alzheimer's drug in nearly two decades. Two big studies of the drug produced conflicting results.
Researchers are using brain scans, blood and spinal fluid to detect early signs of Alzheimer's disease. These "biomarkers" may also offer a quicker way to test new Alzheimer's drugs.
Now that so many experimental drugs targeting amyloid-beta have bombed, scientists are looking for different approaches for treating Alzheimer's, including a drug that failed as a cancer treatment.