The Williams sisters were eliminated by the Czech pair of Lucie Hradecka and Linda Noskova at Flushing Meadows, leaving the court with hugs and a standing ovation.
The BBC's John Inverdale was asking the World No. 2 how it felt to be the first person to win two Olympic gold medals in tennis. "Umm," the Scotsman said, before bringing up Venus and Serena Williams.
Williams defeated her big sister 6-2, 1-6, 6-3. It keeps alive her quest to win each of the year's major tournaments, the first time the feat would be accomplished since Steffi Graf did it in 1988.