President Obama had praised nominee Merrick Garland's collegiality and ability to build consensus, saying "he's shown a rare ability to bring together odd couples."
Clinton beat Sanders in three states. Trump sweeped Florida. Karen Beckwith of Case Western Reserve University of Ohio and Susan MacManus of the University of South Florida weigh in on the races.
Sen. Marco Rubio announced an end to his campaign following a loss in his home state of Florida to Donald Trump. Sitting Ohio Gov. John Kasich dealt Trump his only loss on Tuesday on his home turf.
With David Greene in Ohio and Steve Inskeep in Florida, some Democrat voters say Bernie Sanders pushed Hillary Clinton to be a better candidate. Don Gonyea also has the latest for the Republican side.
MSNBC's Joe Scarborough tweeted: "Smile. You just had a big night." Others commented that she was "shouting angrily." The response to their criticism on Twitter was swift.
Tuesday night's five electoral contests could spell the end of the road for at least two Republican candidates, while Bernie Sanders is hoping Rust Belt wins will boost him against Hillary Clinton.