Francis has a full schedule, which includes a meeting with Cuban President Raul Castro in Havana and President Obama in Washington, D.C., where he will also address a joint meeting of Congress.
The pope spent his first full day in Cuba giving a mass to crowds gathered in Havana's Revolution Plaza, meeting the former president and speaking with Cuba's youth.
The pope celebrated Mass before a huge crowd in Revolution Square in Havana. His visit is intended to show solidarity with Cuba's long-suffering Catholic Church.
The secretary of state said the U.S. would ratchet up the number of migrants Washington accepts over the next few years to help the European Union deal with the ongoing crisis.
On the first full day of his visit to Cuba, the pontiff attracted thousands of people hoping to catch a glimpse of history's first Latin American pope.
The pope arrived in Cuba on Saturday for the start of a 10-day trip that will include his first-ever visit to the U.S. In Cuba, the pope's visit will highlight his role as peacebroker.
Francis will spend several days in the island nation, where he will visit President Raul Castro. In the U.S., the pontiff will meet with President Obama and address Congress and the United Nations.
Childhood malnutrition and unsafe water are no longer in the top 10 of risks for death. But lifestyle-related risks, from smoking to diets high in salt and low in fruits, are killing millions.
The changes that will take effect Monday allow U.S. companies to provide Internet and communications services in Cuba. Air and cruise ship travel will also be easier.